Li Y, Bansal S, Sridharan V, Bansal S, Jayatilake MM, Fernández JA, Griffin JH, Boerma M, Cheema AK. Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction. Metabolites. 2023 Apr 6;13(4):525. doi: 10.3390/metabo13040525. PMID: 37110184; PMCID: PMC10146652.
Nemec-Bakk AS, Sridharan V, Seawright JW, Nelson GA, Cao M, Singh P, Cheema AK, Singh B, Li Y, Koturbash I, Miousse IR, Ewing LE, Skinner CM, Landes RD, Lowery JD, Mao XW, Singh SP, Boerma M. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life Sci Space Res (Amst). 2023 May;37:78-87. doi: 10.1016/j.lssr.2023.03.008. Epub 2023 Mar 30. PMID: 37087182; PMCID: PMC10122719.
Carpenter AD, Li Y, Janocha BL, Wise SY, Fatanmi OO, Maniar M, Cheema AK, Singh VK. Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure. J Proteome Res. 2023 Apr 7;22(4):1116-1126. doi: 10.1021/acs.jproteome.2c00458. Epub 2023 Mar 28. PMID: 36977373; PMCID: PMC10088047.
Bansal S, Bansal S, Fish BL, Li Y, Xu X, Fernandez JA, Griffin JH, Himburg HA, Boerma M, Medhora M, Cheema AK. Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity. Int J Radiat Biol. 2023 Feb 24:1-10. doi: 10.1080/09553002.2023.2182001. Epub ahead of print. PMID: 36827630.
Sridharan V, Krager KJ, Pawar SA, Bansal S, Li Y, Cheema AK, Boerma M. Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart. Cancers (Basel). 2023 Jan 7;15(2):406. doi: 10.3390/cancers15020406. PMID: 36672353; PMCID: PMC9856613.
Cheema AK, Li Y, Ventimiglia M, Kowalczyk K, Hankins R, Bandi G, Janowski EM, Grindrod S, Villagra A, Dritschilo A. Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers. Clin Cancer Res. 2023 Mar 1;29(5):921-929. doi: 10.1158/1078-0432.CCR-22-2340. PMID: 36508164; PMCID: PMC9975665.
Li Y, Girgis M, Jayatilake M, Serebrenik AA, Cheema AK, Kaytor MD, Singh VK. Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates. Sci Rep. 2022 Aug 5;12(1):13475. doi: 10.1038/s41598-022-17807-7. PMID: 35931769; PMCID: PMC9356050.
Cheema AK, Li Y, Moulton J, Girgis M, Wise SY, Carpenter A, Fatanmi OO, Singh VK. Identification of Novel Biomarkers for Acute Radiation Injury Using Multiomics Approach and Nonhuman Primate Model. Int J Radiat Oncol Biol Phys. 2022 Oct 1;114(2):310-320. doi: 10.1016/j.ijrobp.2022.05.046. Epub 2022 Jun 5. PMID: 35675853.
Hinzman CP, Singh B, Bansal S, Li Y, Iliuk A, Girgis M, Herremans KM, Trevino JG, Singh VK, Banerjee PP, Cheema AK. A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells. J Extracell Vesicles. 2022 Jun;11(6):e12232. doi: 10.1002/jev2.12232. PMID: 35656858; PMCID: PMC9164146.
Hinzman CP, Jayatilake M, Bansal S, Fish BL, Li Y, Zhang Y, Bansal S, Girgis M, Iliuk A, Xu X, Fernandez JA, Griffin JH, Ballew EA, Unger K, Boerma M, Medhora M, Cheema AK. An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure. J Transl Med. 2022 May 10;20(1):199. doi: 10.1186/s12967-022-03414-7. PMID: 35538547; PMCID: PMC9092707.
Hsu CC, Bansal S, Cao H, Smith CI, He AR, Gay MD, Li Y, Cheema A, Smith JP. Safety and Pharmacokinetic Assessment of Oral Proglumide in Those with Hepatic Impairment. Pharmaceutics. 2022 Mar 12;14(3):627. doi: 10.3390/pharmaceutics14030627. PMID: 35336003; PMCID: PMC8948956.
Rajagopal MU, Bansal S, Kaur P, Jain SK, Altadil T, Hinzman CP, Li Y, Moulton J, Singh B, Bansal S, Chauthe SK, Singh R, Banerjee PP, Mapstone M, Fiandaca MS, Federoff HJ, Unger K, Smith JP, Cheema AK. TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC. Cancers (Basel). 2021 Dec 9;13(24):6204. doi: 10.3390/cancers13246204. PMID: 34944824; PMCID: PMC8699757.
Li Y, Girgis M, Wise SY, Fatanmi OO, Seed TM, Maniar M, Cheema AK, Singh VK. Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure. Sci Rep. 2021 Jun 1;11(1):11449. doi: 10.1038/s41598-021-91067-9. PMID: 34075191; PMCID: PMC8169671.
Singh VK, Seed TM, Cheema AK. Metabolomics-based predictive biomarkers of radiation injury and countermeasure efficacy: current status and future perspectives. Expert Rev Mol Diagn. 2021 Jul;21(7):641-654. doi: 10.1080/14737159.2021.1933448. Epub 2021 Jun 7. PMID: 34024238.
Dissmore T, DeMarco AG, Jayatilake M, Girgis M, Bansal S, Li Y, Mehta K, Sridharan V, Gill K, Bansal S, Tyburski JB, Cheema AK. Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation. J Environ Sci Health C Toxicol Carcinog. 2021;39(2):219-233. doi: 10.1080/26896583.2020.1865027. PMID: 33902389; PMCID: PMC9896584.
Girgis M, Li Y, Jayatilake M, Gill K, Wang S, Makambi K, Sridharan V, Cheema AK. Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation. J Environ Sci Health C Toxicol Carcinog. 2021;39(2):234-249. doi: 10.1080/26896583.2020.1868866. PMID: 33902388; PMCID: PMC9757021.
Li Y, Singh J, Varghese R, Zhang Y, Fatanmi OO, Cheema AK, Singh VK. Transcriptome of rhesus macaque (Macaca mulatta) exposed to total-body irradiation. Sci Rep. 2021 Mar 18;11(1):6295. doi: 10.1038/s41598-021-85669-6. PMID: 33737626; PMCID: PMC7973550.
LaPelusa M, Donoviel D, Branzini SE, Carlson PE Jr, Culler S, Cheema AK, Kaddurah-Daouk R, Kelly D, de Cremoux I, Knight R, Krajmalnik-Brown R, Mayo SL, Mazmanian SK, Mayer EA, Petrosino JF, Garrison K. Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop. Microbiome
Cheema AK, Kaur P, Fadel A, Younes N, Zirie M, Rizk NM. Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes
Cheema AK, Li Y, Girgis M, Jayatilake M, Fatanmi OO, Wise SY, Seed TM, Singh VK. Alterations in Tissue Metabolite Profiles with Amifostine-Prophylaxed Mice Exposed to Gamma Radiation. Metabolites
Coia H, Ma N, Hou Y, Permaul E, Berry DL, Cruz MI, Pannkuk E, Girgis M, Zhu Z, Lee Y, Rodriquez O, Cheema A, Chung FL. Theaphenon E prevents fatty liver disease and increases CD4+ T cell survival in mice fed a high-fat diet. Clin Nutr
Garty G, Xu Y, Johnson GW, Smilenov LB, Joseph SK, Pujol-Canadell M, Turner HC, Ghandhi SA, Wang Q, Shih R, Morton RC, Cuniberti DE, Morton SR, Bueno-Beti C, Morgan TL, Caracappa PF, Laiakis EC, Fornace AJ Jr, Amundson SA, Brenner DJ. VADER: a variable dose-rate external 137Cs irradiator for internal emitter and low dose rate studies. Sci Rep
Girgis M, Li Y, Ma J, Sanda M, Wise SY, Fatanmi OO, Kaytor MD, Cheema AK, Singh VK. Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure. Sci Rep
Kurnat-Thoma E, Baranova A, Baird P, Brodsky E, Butte AJ, Cheema AK, Cheng F, Dutta S, Grant C, Giordano J, Maitland-van der Zee AH, Fridsma DB, Jarrin R, Kann MG, Keeney J, Loscalzo J, Madhavan G, Maron BA, McBride DK, McKean M, Mun SK, Palmer JC, Patel B, Parakh K, Pariser AR, Pristipino C, Radstake TRDJ, Rajasimha HK, Rouse WB, Rozman D, Saleh A, Schmidt HHHW, Schultz N, Sethi T, Silverman EK, Skopac J, Svab I, Trujillo S, Valentine JE, Verma D, West BJ, Vasudevan S. Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. Syst Med
Laiakis EC, McCart EA, Deziel A, Rittase WB, Bouten RM, Jha J, Wilkins WL, Day RM, Fornace AJ Jr. Effect of 3,3’-diindolylmethane on Pulmonary Injury Following Thoracic Irradiation in CBA mice. Health Phys
Li HH, Lin YT, Laiakis EC, Goudarzi M, Weber W, Fornace AJ Jr. Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates. Metabolites
Mak TD, Goudarzi M, Laiakis EC, Stein SE. Disparate Metabolomics Data Reassembler: A Novel Algorithm for Agglomerating Incongruent LC-MS Metabolomics Datasets. Anal Chem
Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer’s disease in adults with Down syndrome. Alzheimers Dement (Amst)
Pannkuk EL, Laiakis EC, Ake P, Strawn SJ, Wang YW, Fornace AJ Jr. Effects of Genetic Variation on Urinary Small Molecule Signatures of Mice after Exposure to Ionizing Radiation: A Study of p53 Deficiency. Metabolites
Sasaki JC, Allemang A, Bryce SM, Custer L, Dearfield KL, Dietz Y, Elhajouji A, Escobar PA, Fornace AJ Jr, Froetschl R, Galloway S, Hemmann U, Hendriks G, Li HH, Luijten M, Ouedraogo G, Peel L, Pfuhler S, Roberts DJ, Thybaud V, van Benthem J, Yauk CL, Schuler M. Application of the adverse outcome pathway framework to genotoxic modes of action. Environ Mol Mutagen
Suman S, Shuryak I, Kallakury B, Brenner DJ, Fornace AJ Jr, Johnson MD, Datta K. Protons Show Greater Relative Biological Effectiveness for Mammary Tumorigenesis with Higher ERα- and HER2-Positive Tumors Relative to γ-rays in APCMin/+ Mice. Int J Radiat Oncol Biol Phys
Tan M, Mosaoa R, Graham GT, Kasprzyk-Pawelec A, Gadre S, Parasido E, Catalina-Rodriguez O, Foley P, Giaccone G, Cheema A, Kallakury B, Albanese C, Yi C, Avantaggiati ML. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ
Turck CW, Mak TD, Goudarzi M, Salek RM, Cheema AK. The ABRF Metabolomics Research Group 2016 Exploratory Study: Investigation of Data Analysis Methods for Untargeted Metabolomics. Metabolites
Unger K, Li Y, Yeh C, Barac A, Srichai MB, Ballew EA, Girgis M, Jayatilake M, Sridharan V, Boerma M, Cheema AK. Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity. Radiother Oncol
Upadhyay M, Rajagopal M, Gill K, Li Y, Bansal S, Sridharan V, Tyburski JB, Boerma M, Cheema AK. Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model. Metabolites
Vera NB, Coy SL, Laiakis EC, Fornace AJ Jr, Clasquin M, Barker CA, Pfefferkorn JA, Vouros P. Quantitation of Urinary Acylcarnitines by DMS-MS/MS Uncovers the Effects of Total Body Irradiation in Cancer Patients. J Am Soc Mass Spectrom
Zhang M, Jiang N, Chu Y, Postnikova O, Varghese R, Horvath A, Cheema AK, Golestaneh N. Dysregulated metabolic pathways in age-related macular degeneration. Sci Rep
Bearden DW, Sheen DA, Simón-Manso Y, Benner BA Jr, Rocha WFC, Blonder N, Lippa KA, Beger RD, Schnackenberg LK, Sun J, Mehta KY, Cheema AK, Gu H, Marupaka R, Nagana Gowda GA, Raftery D. Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite. Metabolites
Cheema AK, Grindrod S, Zhong X, Jain S, Menon SS, Mehta KY, Suy S, Collins S, Wang Y, Timofeeva O, Bandi G, Pahira J, Kowalczyk K, Lynch J, Dritschilo A. Discovery of Metabolic Biomarkers Predicting Radiation Therapy Late Effects in Prostate Cancer Patients. Adv Exp Med Biol
Cheema AK, Li Y, Girgis M, Jayatilake M, Simas M, Wise SY, Olabisi AO, Seed TM, Singh VK. Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation. Sci Rep
Cheema AK, Mehta KY, Rajagopal MU, Wise SY, Fatanmi OO, Singh VK. Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation. Int J Mol Sci
Cheema AK, Mehta KY, Santiago PT, Fatanmi OO, Kaytor MD, Singh VK. Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model. Int J Mol Sci
Cho E, Buick JK, Williams A, Chen R, Li HH, Corton JC, Fornace AJ Jr, Aubrecht J, Yauk CL. Assessment of the performance of the TGx-DDI biomarker to detect DNA damage-inducing agents using quantitative RT-PCR in TK6 cells. Environ Mol Mutagen
Czarnecka M, Lu C, Pons J, Maheswaran I, Ciborowski P, Zhang L, Cheema AK, Kitlinska J (2019) Neuropeptide Y receptor interactions regulate its mitogenic activity. Neuropeptides
Divekar SD, Li HH, Parodi DA, Ghafouri TB, Chen R, Cyrus K, Foxworth AE, Fornace AJ, Byrne C, Martin MB. Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis
Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer’s disease. Dev Neurobiol. 2019;79(7):622-638
Hinzman CP, Baulch JE, Mehta KY, Girgis M, Bansal S, Gill K, Li Y, Limoli CL, Cheema AK. Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice. Sci Rep. 2019;9(1):9460
Kumar S, Suman S, Fornace AJ, Datta K. Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice. Aging
Laiakis EC, Canadell MP, Grilj V, Harken AD, Garty GY, Astarita G, Brenner DJ, Smilenov L, Fornace AJ Jr. Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype. Sci Rep
Laiakis EC, Nishita D, Bujold K, Jayatilake MM, Bakke J, Gahagen J, Authier S, Chang P, Fornace AJ Jr. Salivary Metabolomics of Total Body Irradiated Nonhuman Primates Reveals Long-Term Normal Tissue Responses to Radiation. Int J Radiat Oncol Biol Phys
Maimouni S, LEE MH, Sung YM, Hall M, Roy A, Quaari C, Hwang YS, Spivak J, Glasgow E, Swift M, Patel J, Cheema AK, Kumar D, Byers S (2019) Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Oncotarget
Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema AK, Hauer-Jensen M, Boerma M, Koturbash I. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life Sci Space Res (Amst)
Mukherjee S, Laiakis EC, Fornace AJ Jr, Amundson SA. Impact of inflammatory signaling on radiation biodosimetry: mouse model of inflammatory bowel disease. BMC Genomics
Pannkuk EL, Laiakis EC, Gill K, Jain SK, Mehta KY, Nishita D, Bujold K, Bakke J, Gahagen J, Authier S, Chang P, Fornace AJ Jr. Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels. J Proteome Res
Pannkuk EL, Laiakis EC, Girgis M, Dowd SE, Dhungana S, Nishita D, Bujold K, Bakke J, Gahagen J, Authier S, Chang PY, Fornace AJ. Temporal Effects on Radiation Responses in Nonhuman Primates: Identification of Biofluid Small Molecule Signatures by Gas Chromatography⁻Mass Spectrometry Metabolomics. Metabolites
Suman S, Kallakury BVS, Fornace AJ Jr, Datta K. Fractionated and Acute Proton Radiation Show Differential Intestinal Tumorigenesis and DNA Damage and Repair Pathway Response in ApcMin/+ Mice. Int J Radiat Oncol Biol Phys
Taraboletti A, Goudarzi M, Kabir A, Moon BH, Laiakis EC, Lacombe J, Ake P, Shoishiro S, Brenner D, Fornace AJ Jr, Zenhausern F. Fabric Phase Sorptive Extraction-A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment. J Proteome Res
Ferrarini A, Di Poto C, He S, Tu C, Varghese RS, Kara Balla A, Jayatilake M, Li Z, Ghaffari K, Fan Z, Sherif ZA, Kumar D, Kroemer A, Tadesse MG, Ressom HW. Metabolomic Analysis of Liver Tissues for Characterization of Hepatocellular Carcinoma. J Proteome Res Y receptor interactions regulate its mitogenic activity. Neuropeptides
Maimouni S, Issa N, Cheng S, Ouaari C, Cheema AK, Kumar D, Byers S (2018) Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells. PLoS One
Cheema AK, Hinzman CP, Mehta KY, Hanlon BK, Garcia M, Fatanmi OO, Singh VK (2018) Plasma Derived Exosomal Biomarkers of Exposure to Ionizing Radiation in Nonhuman Primates. Int J Mol Sci
Getnet D, Gautam A, Kumar R, Hoke A, Cheema AK, Rossetti F, Schultz CR, Hammamieh R, Lumley LA, Jett M (2018) Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a case for Novel Signatures for Asymptomatic Nerve Agent Exposure. Appl Environ Microbiol
Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema, AK, Mapstone M, Federoff HJ (2018) Potential Metabolomic Linkage in Blood between Parkinson’s Disease and Traumatic Brain Injury. Metabolites
Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW (2018) Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep
Cheema AK, Byrum S, Sharma NK, Altadill T, Kumar V, Biswas S, Balgley B, Hauer-Jensen M, Tackett A, Ghosh S (2018) Proteomic changes in mouse spleen following radiation injury and its modulation by gamma-tocotrienol. Radiat Res
Hinzman C, Baulch J, Mehta K, Gill K, Limoli C, Cheema AK (2018) Exposure to ionizing radiation causes endoplasmic reticulum (ER) stress in mouse hippocampus. Radiat Res
Unger K, Mehta KY, Kaur P, Wang Y, Menon SS, Jain SK, Moonjelly RA, Suman S, Datta K, Singh R, Fogel P, Cheema AK (2018) Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma. Oncotarget
Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ (2018) Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One
Fernandez HR, Gadre SM, Tan M, Graham GT, Mosaoa R, Ongkeko MS, Kim KA, Riggins RB, Parasido E, Petrini I, Pacini S, Cheema AK, Varghese R, Ressom HW, Zhang Y, Albanese C, Üren A, Paige M, Giaccone G, Avantaggiati ML (2018) The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ
Deeken JF, Wang H, Hartley M, Cheema AK, Smaglo B, Hwang JJ, He AR, Weiner LM, Marshall JL, Giaccone G, Liu S, Luecht J, Spiegel JY, Pishvaian MJ (2018) A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies. Cancer Chemother Pharmacol
Chakraborty N, Cheema AK, Gautam A, Donohue D, Hoke A, Conley C, Jett M, Hammamieh R (2018) Gene-metabolite profile integration to understand the cause of spaceflight induced immunodeficiency. NPJ Microgravity
Gross T, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS (2018) Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development. Curr Top Med Chem
Cheema AK, Mehta KY, Fatanmi OO, Wise SY, Hinzman CP, Wolff J, Singh VK (2017) A metabolomic and lipidomic serum signature from nonhuman primates administered with a promising radiation countermeasure, gamma-tocotrienol. Int J Mol Sci
Shajahan-Haq AN, Boca SM, Jin L, Bhuvaneshwar K, Gusev Y, Cheema AK, Demas DD, Raghavan KS, Michalek R, Madhavan S, Clarke R (2017) EGR1 regulates cellular metabolism and survival in endocrine resistant breast cancer. Oncotarget
Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, Cheema AK (2017) Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget
Altadill T, Dowdy TM, Gill K, Reques A, Menon SS, Moiola CP, Lopez-Gil C, Coll E, Matias-Guiu X, Cabrera S, Garcia A, Reventos J, Byers SW, Gil-Moreno A, Cheema AK, Colas E (2017) Metabolomic and lipidomic profiling identifies the role of the RNA editing pathway in endometrial carcinogenesis. Sci Rep
Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK (2017) Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome
Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I (2017) One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts
Woodrick J, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema AK, Bai Y, Khatkar P, Erkizan HV, Sami F, Su Y, Schärer OD, Sharma S, Roy R (2017) A new sub-pathway of long-patch base excision repair involving 5’ gap formation. EMBO
Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff HJ (2017) Biomarker validation: Methods and matrix matter. Alzheimers Dement
Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ (2017) What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer’s disease. Neurobiol Aging
Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M (2016) Effects of ionizing radiation on the heart. Mutat Res
Matos Do Canto L, Marian C, Varghese RS, Ahn J, Da Cunha PA, Willey S, Sidawy M, Rone JD, Cheema AK, Luta G, Nezami Ranjbar MR, Ressom HW, Haddad BR (2016) Metabolomic profiling of breast tumors using ductal fluid. Int J Oncol
Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG (2016) Menthol smokers: Metabolomic profiling and smoking behavior. Cancer Epidemiol Biomarkers Prev
Boca SM, Nishida M, Harris M, Rao S, Cheema AK, Gill K, Wang D, An L, Gauba R, Seol H, Morgenroth LP, Henricson E, McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S (2016) Correction: Discovery of metabolic biomarkers for duchenne muscular dystrophy within a natural history study. PLoS One
Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG (2016) Metabolomic profiles of current cigarette smokers. Mol Carcinog
Boca SM, Nishida M, Harris M, Rao S, Cheema AK, Gill K, Seol H, Morgenroth LP, Henricson E, McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S (2016) Discovery of metabolic biomarkers for duchenne muscular dystrophy within a natural history study. PLoS One
Cheema AK, Maier I, Dowdy T, Wang Y, Singh R, Ruegger PM, Borneman J, Fornace AJ Jr, Schiestl RH (2016) Chemopreventive metabolites are correlated with a change in intestinal microbiota measured in a-t mice and decreased carcinogenesis. PLoS One
Altadill T, Campoy I, Lanau L, Gill K, Rigau M, Gil-Moreno A, Reventos J, Byers S, Colas E, Cheema AK (2016) Enabling metabolomics based biomarker discovery studies using molecular phenotyping of exosome-like vesicles. PLoS One
Menon SS, Uppal M, Randhawa S, Cheema MS, Aghdam N, Usala RL, Ghosh SP, Cheema AK, Dritschilo A (2016) Radiation metabolomics: Current status and future directions. Front Oncol
Cao L, Liu P, Gill K, Reece EA, Cheema AK, Zhao Z (2016) Identification of novel cell survival regulation in diabetic embryopathy via phospholipidomic profiling. Biochem Biophys Res Commun
Pathak R, Cheema AK, Boca SM, Krager KJ, Hauer-Jensen M, Aykin-Burns N (2015) Modulation of radiation response by the tetrahydrobiopterin pathway. Antioxidants (Basel)
Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ (2015) Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease. Front Neurol
Cheema AK, Asara JM, Wang Y, Neubert TA, Tolstikov V, Turck CW (2015) The ABRF metabolomics research group 2013 study: Investigation of spiked compound differences in a human plasma matrix. J Biomol Tech
Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff HJ, Newport EL (2015) Critical periods after stroke study: Translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci
Kong H, Song JK, Yenugonda VM, Zhang L, Shuo T, Cheema AK, Kong Y, Du GH, Brown ML (2015) Preclinical studies of the potent and selective nicotinic α4β2 receptor ligand VMY-2-95. Mol Pharm
Sengupta M, Cheema AK, Kaminski HJ, Kusner LL; Muscle Study Group (2014) Serum metabolomic response of myasthenia gravis patients to chronic prednisone treatment. PLoS One
Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ (2014) The critical need for defining preclinical biomarkers in Alzheimer’s disease. Alzheimers Dement
Cheema AK, Pathak R, Zandkarimi F, Kaur P, Alkhalil L, Singh R, Zhong X, Ghosh S, Aykin-Burns N, Hauer-Jensen M (2014) Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. J Proteome Res
Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ (2014) Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med
Cheema AK, Suman S, Kaur P, Singh R, Fornace AJ Jr, Datta K (2014) Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure. PLoS One
Madhavan S, Gusev Y, Natarajan TG, Song L, Bhuvaneshwar K, Gauba R, Pandey A, Haddad BR, Goerlitz D, Cheema AK, Juhl H, Kallakury B, Marshall JL, Byers SW, Weiner LM (2013) Genome-wide multi-omics profiling of colorectal cancer identifies immune determinants strongly associated with relapse. Front Genet
Cheema AK, Varghese RS, Timofeeva O, Zhang L, Kirilyuk A, Zandkarimi F, Kaur P, Ressom HW, Jung M, Dritschilo A (2013) Functional proteomics analysis to study ATM dependent signaling in response to ionizing radiation. Radiat Res
Pathak R, Pawar SA, Fu Q, Gupta PK, Berbée M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M (2013) Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal
Ghosh SP, Singh R, Chakraborty K, Kulkarni S, Uppal A, Luo Y, Kaur P, Pathak R, Kumar KS, Hauer-Jensen M, Cheema AK (2013) Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model. Mol Biosyst
Timofeeva OA, Tarasova N,I Zhang X, Chasovskikh S, Cheema AK, Wang H, Brown ML, Dritschilo A (2013) STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proc. Natl. Acad. Sci. U.S.A.
Kaur P, Rizk N, Ibrahim S, Luo Y, Younes N, Perry B, Dennis K, Zirie M, Luta G, Cheema AK (2013) Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes. Mol Biosyst
Hsu PC, Zhou B, Zhao Y, Ressom HW, Cheema AK, Pickworth W, Shields PG (2013) Feasibility of identifying the tobacco-related global metabolome in blood by UPLC-QTOF-MS. J Proteome Res
Xiao JF, Varghese RS, Zhou B, Nezami Ranjbar MR, Zhao Y, Tsai TH, Di Poto C, Wang J, Goerlitz D, Luo Y, Cheema AK, Sarhan N, Soliman H, Tadesse MG, Ziada DH, Ressom HW (2012) LC-MS based serum metabolomics for identification of hepatocellular carcinoma biomarkers in Egyptian cohort. J Proteome Res
Kaur P, Rizk NM, Ibrahim S, Younes N, Uppal A, Dennis K, Karve T, Blakeslee K, Kwagyan J, Zirie M, Ressom HW, Cheema AK (2012) iTRAQ-based quantitative protein expression profiling and MRM verification of markers in type 2 diabetes. J Proteome Res
Schlottmann S, Erkizan HV, Barber-Rotenberg JS, Knights C, Cheema AK, Uren A, Avantaggiati ML, Toretsky JA (2012) Acetylation increases EWS-FLI1 DNA binding and transcriptional activity. Front Oncol
Ressom HW, Xiao JF, Tuli L, Varghese RS, Zhou B, Tsai TH, Ranjbar MR, Zhao Y, Wang J, Di Poto C, Cheema AK, Tadesse MG, Goldman R, Shetty K (2012) Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta
Timofeeva OA, Chasovskikh S, Lonskaya I, Tarasova NI, Khavrutskii L, Tarasov SG, Zhang X, Korostyshevskiy VR, Cheema AK, Zhang L, Dakshanamurthy S, Brown ML, Dritschilo A (2012) Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. J Biol Chem
Tuli L, Tsai TH, Varghese RS, Xiao JF, Cheema AK, Ressom HW (2012) Using a spike-in experiment to evaluate analysis of LC-MS data. Proteome Sci
Karve TM, Cheema AK (2011) Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease. J Amino Acids
Tang Z, Zhang L, Cheema AK, Ressom HW (2011) A new method for alignment of LC-MALDI-TOF data. Proteome Sci
Jung M, Timofeeva O, Cheema AK, Varghese R, Ressom H, Dritschilo A (2011) Human fibroblasts for large-scale “omics” investigations of ATM gene function. Adv Exp Med Biol
Coy SL, Cheema AK, Tyburski JB, Laiakis EC, Collins SP, Fornace A Jr (2011) Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol
Sheikh KD, Khanna S, Byers SW, Fornace A Jr, Cheema AK (2011) Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome. J Biomol Tech
Deb TB, Zuo AH, Wang Y, Barndt RJ, Cheema AK, Sengupta S, Coticchia CM, Johnson MD (2011) Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex. Am J Physiol Cell Physiol
Cheema AK, Timofeeva O, Varghese R, Dimtchev A, Shiekh K, Shulaev V, Suy S, Collins S, Ressom H, Jung M, Dritschilo A (2011) Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism. J Proteome Res
Abu-Asab MS, Chaouchi M, Alesci S, Galli S, Laassri M, Cheema AK, Atouf F, VanMeter J, Amri H (2011) Biomarkers in the age of omics: Time for a systems biology approach. OMICS
Zhou B, Cheema AK, Ressom HW (2010) SVM-based spectral matching for metabolite identification. Conf Proc IEEE Eng Med Biol Soc
Sahab ZJ, Hall MD, Zhang L, Cheema AK, Byers SW (2010) Tumor suppressor RARRES1 regulates DLG2, PP2A, VCP, EB1, and Ankrd26. J Cancer
Cheema AK, Knights CD, Rao M, Catania J, Perez R, Simons B, Dakshanamurthy S, Kolukula VK, Tilli M, Furth PA, Albanese C, Avantaggiati ML (2010) Functional mimicry of the acetylated C-terminal tail of p53 by a SUMO-1 acetylated domain, SAD. J Cell Physiol
Varghese RS, Cheema AK, Cheema P, Bourbeau M, Tuli L, Zhou B, Jung M, Dritschilo A, Ressom HW (2010) Analysis of LC-MS data for characterizing the metabolic changes in response to radiation. J Proteome Res
Timofeeva OA, Zhang X, Ressom HW, Varghese RS, Kallakury BV, Wang K, Ji Y, Cheema AK, Jung M, Brown ML, Rhim JS, Dritschilo A (2009) Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men. Int J Oncol
Ballal R, Cheema AK, Ahmad W, Rosen EM, Saha T (2009) Fluorescent oligonucleotides can serve as suitable alternatives to radiolabeled oligonucleotides. J Biomol Tech
Mi L, Gan N, Cheema AK, Dakshanamurthy S, Wang X, Yang DC, Chung FL (2009) Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J Biol Chem
Hu ZZ, Huang H, Cheema AK, Jung M, Dritschilo A, Wu CH (2008) Integrated bioinformatics for radiation-induced pathway analysis from proteomics and microarray data. J Proteomics Bioinform
Choudhury S, Adhikari S, Cheema AK, Roy R (2008) Evidence of complete cellular repair of 1,N6-ethenoadenine, a mutagenic and potential damage for human cancer, revealed by a novel method. Mol Cell Biochem
Wong CM, Cheema AK, Zhang L, Suzuki YJ (2008) Protein carbonylation as a novel mechanism in redox signaling. Circ Res
Emami A, Dyba M, Cheema AK, Pan J, Nath RG, Chung FL (2008) Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: Blocking its artifact formation with glutathione. Anal Biochem